27 May Neuropathy Relief Center Of Miami Research Review: Differential efficacy of methylcobalamin (B-12) and alpha-lipoic acid (Omega-3) treatment on symptoms of diabetic peripheral neuropathy
Omega-3 reduced burning and pain
B-12 reduced numbness and paresthesia
Background: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy
following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection.
Methods: Forty DPN patients were randomly divided into MC and ALA treatment groups (both N.=20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment. Serum malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured.
Results: Neuropathy as measured by TCSS, TSS, and VAS scores was significantly reduced by both treatments
(P<0.05) but magnitude varied by symptom. The VAS score reductions for burning and pain were significantly greater following ALA (P<0.01), while MC reduced numbness and paresthesia VAS scores to a slightly greater extent than ALA (P>0.05). Numbers of abnormal (low-response) points for pressure and pinprick sensation were reduced by MC but not by ALA, while both treatments induced a significant reduction in vibratory perception threshold (P<0.01). Neither MC nor ALA improved temperature sensation or tendon reflexes (P>0.05). Alpha-lipoic acid, increased SOD and reduced MDA (P<0.05), indicating enhanced antioxidant capacity, while MC had no effect.
Conclusions: Due to differences in efficacy, MC or ALA should be chosen according to the symptoms of individual patients.
Neuropathy Symptoms Or Diagnosis? What should I do next?
If you have been diagnosed with Neuropathy or have neuropathy symptoms such as pain, burning, numbness in your arms, hands, legs or feet. Please contact us at (305) 275-7475 to schedule and discuss your questions with our new patient specialist or message us your number/email and our team member will reach out to you for scheduling.
Dr. Alfonso‘s Neuropathy Treatment Protocol is a highly successful drugless, non-invasive, safe, and effective treatment that has successfully helped many patients who suffer from Diabetic Neuropathy.
Out of town patients can schedule a complimentary WhatsApp, Zoom Meeting Consultation or Phone Consultation with Dr. Alfonso. Please contact us via website, email, or by phone if you have any questions. We are here to help you overcome neuropathy and get you back to enjoying life!
For more info on the Dr. Alfonso Neuropathy Treatment Protocol please visit our treatment page of our website.
I look forward to meeting and helping you!
Sincerely Yours for Health,
Dr. Rodolfo Alfonso, D.C.
8585 Sunset Drive,
Miami, FL 33143