The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.

Biological Characteristics -mesenchymal stem cells.

The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.

High blood sugar is a major factor causing damage to many parts of the body resulting in neuropathy symptoms and dysfunction.

Research is now discovering this damage to occur in structures and tissues unexpected in the past. High blood sugar is a major cause of the decrease circulation causing death to the    nerves in sensory peripheral neuropathy. From this new research we can see that elevated blood sugar also contributes to spinal disc damage contributing to the cause of compression forms of Neuropathy.

SIGNIFICANCE OF THE STUDY: We found that high glucose concentration significantly decreased cell proliferation, colony formation ability, migration and wound-healing capability of nucleus pulposus-derived mesenchymal stem cells. Moreover, high glucose cultured nucleus pulposus-derived mesenchymal stem cells showed significantly decreased expression of stemness genes, related mRNA and protein, whereas increased cell apoptosis, cell senescence and expression of caspase-3.


The present study indicated that better control of high concentration glucose in the early stage of diabetes mellitus should be recommended to prevent or limit intervertebral disc degeneration.

The Neuropathy Relief Miami team goes beyond conventional medicine by offering services and techniques which can relieve peripheral neuropathy symptoms while at the same time addressing and resolving the underlying causes of your neuropathy.

Dr.  Alfonso‘s Neuropathy Treatment Protocol is a highly successful drug-free, non surgical, safe, and effective treatment that has successfully helped many patients who suffer from Neuropathy.

Using the latest research and technology, Dr. Alfonso’s Neuropathy Treatment Protocol is based on the most advanced science and technologies available.

This Treatment Protocol, which is implemented without medications or surgery, combines a customized treatment plan, home care, and nutritional program.

If you have been diagnosed with peripheral neuropathy or experience neuropathy symptoms such as pain, burning, coldness, discoloration, wounds, numbness in your arms, hands, legs or feet, or balance and walking difficulties.

Please call our South Miami office (305) 275-7475 to schedule a Free consultation or reserve a spot at our Free Neuropathy Seminar!

You can also easily setup an appointment online.


I will teach you the true causes of neuropathy and discover a new innovative neuropathy treatment that has improved the lives of patients not only in South Miami but across the world.
I look forward to meeting and helping you and

Sincerely Yours for Health,
Dr. Rodolfo Alfonso

8585 Sunset Drive,
Miami, FL 33143
Ph: 305-275.7475

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