08 Jul Neuropathy Relief Center of Miami Research Review: The change of HCN1/HCN2 mRNA expression in peripheral nerve after chronic constriction injury induced neuropathy followed by pulsed electromagnetic field therapy
“Our results indicated that PEMF can promote nerve regeneration and could be used for the treatment of neuropathic pain.”
Neuropathic pain is usually defined as a chronic pain state caused by peripheral or central nerve injury as a result of acute damage or systemic diseases.
It remains a difficult disease to treat. Recent studies showed that the frequency of action potentials in nociceptive afferents is affected by the activity of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) family. In the current study, we used a neuropathy rat model induced by chronic constriction injury (CCI) of sciatic nerve to evaluate the change of expression of HCN1/HCN2 mRNA in peripheral nerve and spinal cord. Rats were subjected to CCI with or without pulsed electromagnetic field (PEMF) therapy. It was found that CCI induced neural cell degeneration while PEMF promoted nerve regeneration as documented by Nissl staining.
CCI shortened the hind paw withdrawal latency (PWL) and hind paw withdrawal threshold (PWT) and PEMF prolonged the PWL and PWT. In addition, CCI lowers the expression of HCN1 and
HCN2 mRNA and PEMF cannot restore the expression of HCN1 and HCN2 mRNA. Our results indicated that PEMF can promote nerve regeneration and could be used for the treatment of neuropathic pain.
Below are twelve common symptoms experienced by people suffering from peripheral neuropathy in the extremities (arm, hand, leg and/or feet) we see and treat at Neuropathy Relief Center of Miami.
- burning pains
- sharp pains
- numbness and tingling
- pins and needles
- restless leg syndrome
- balance and
- walking difficulties
- balance issues
- arms and legs feeling tired and heavy
Dr. Alfonso‘s Neuropathy Treatment Protocol is a highly successful drug-free, non surgical, safe, and effective treatment that has successfully helped many patients who suffer from Neuropathy.
Dr. Alfonso Neuropathy Treatment Protocol
● Improves and increases oxygen and nutrition through the increase of circulation to the damaged nerves.
● Repairs peripheral fibers by stimulating regenerative of new nerve cells.
● Removes and eliminates mechanical peripheral nerve entrapments and compressions in the spine and extremities
If you have been diagnosed with Neuropathy or have neuropathy symptoms such as pain, burning, numbness in your arms, hands, legs or feet. Please contact us at (305) 275-7475 to schedule and discuss your questions with our new patient specialist or message us your number/email and our team member will reach out to you for scheduling.
Out of town patients can schedule a complimentary Zoom Meeting Consultation, WhatsApp, or Phone Consultation with Dr. Alfonso. Please contact us via website, email, or by phone if you have any questions and to learn more about our Intensive Neuropathy Care for out of town patients. We are here to help you overcome neuropathy and get you back to enjoying life! For more info on the Dr. Alfonso Neuropathy Treatment Protocol please visit our treatment page of our website.
I look forward to meeting and helping you!
Sincerely Yours for Health,
Dr. Rodolfo Alfonso, D.C.
8585 Sunset Drive,
Miami, FL 33143