09 Nov Neuropathy Relief Center of Miami Research Review: Effect of photobiomodulation on serum neuron specific enolase (NSE) among patients with diabetic peripheral neuropathy – A pilot study
Background and aim: Photobiomodulation is an emerging therapy for Diabetic peripheral neuropathy (DPN) of which the management is still a dilemma for clinicians. Elevated Neuron Specific Enolase (NSE) is associated with neuropathy. We aimed this study to assess the effect of Low Level Laser Therapy (LLLT) on Serum Neuron Specific Enolase in Type II Diabetes Mellitus patients with DPN.
Methodology: Pre post interventional study was done on 50 patients with DPN. DPN was confirmed using 10g Monofilament test, Vibration perception threshold (VPT) and Michigan Neuropathy Screening Instrument. All patients were provided with LLLT for 9 min on dorsal and plantar of foot with a dosage of 3.1 J/cm 2 for 10 days. A blood sample was collected at baseline and 4 weeks after LLLT for NSE estimation.
Result: A significant reduction in serum NSE levels (0.006) after 4 weeks of laser therapy was observed in 42 patients when compared with baseline. A significant reduction in the vibration perception threshold (p = 0.003) and Numeric pain rating scale (p = 0.004) were observed.
Conclusion: In this pilot study, we have assessed the effect of LLLT on serum NSE levels among patients with DPN and showed improved quality of life and decrease in serum NSE levels. These findings should be investigated in larger trials.
It is estimated that 55-75% of diabetic patients will experience peripheral neuropathy symptoms such as tingling in hands due to the sensory nerve damage as a result of high blood sugar obstructing the blood flow to the peripheral nerve fibers of the upper extremities.
More than 20 million in the US suffer from peripheral neuropathy. The majority are over the age of 45. That’s almost 1 out of 17 Americans who will develop peripheral neuropathy.
Red light Infrared Light Therapy
Light Infrared Therapy rehabilitates damaged nerves by using specific wavelengths to:
- Increasing Circulation
- Increasing Oxygen
- Increasing Nutrition
- Decreasing Inflammation
- Decreasing Pain
Dr. Alfonso‘s Neuropathy Treatment Protocol utilizes 8 specialized treatments designed to improve the supply of oxygen, eliminate waste, and improve nutrition to damaged nerves. Increased circulation to the damaged peripheral nerves combined with treatments to stimulate peripheral nerve cell regeneration, and repair.
Dr. Alfonso Neuropathy Treatment Protocol
- Improves and increases oxygen and nutrition through the increase of circulation to the damaged nerves.
- Repairs peripheral fibers by stimulating regenerative of new nerve cells.
- Removes and eliminates mechanical peripheral nerve entrapments and compressions in the spine and extremities
Dr. Alfonso will select the best treatment therapy combination, frequency, nutritional plan, and home support determined from your consultation, examination and diagnostics.
For more info on the Dr. Alfonso Neuropathy Treatment Protocol please visit our treatment page of our website.
Dr. Rodolfo Alfonso, D.C.
Neuropathy Relief Center Of Miami
8585 Sunset Dr. STE 104
Miami, Florida 33143