10 Oct Neuropathy Relief Center Of Miami Research Review: Duloxetine for prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN): systematic review and meta-analysis
“There is currently limited evidence supporting duloxetine’s use for CIPN. There is a need for more comprehensive and higher-quality trials assessing duloxetine in the setting of CIPN,
before further clinical practice recommendations.”
Introduction: Duloxetine has previously been reported to be promising in the setting of chemotherapy-induced peripheral neuropathy (CIPN). The aim of this study was to conduct a
comprehensive systematic review and meta-analysis, on the use of duloxetine in prevention and treatment of CIPN.
Methods: PubMed, Embase and Cochrane CENTRAL were searched from database inception up until April 2022. Articles were included in this review if they reported on duloxetine use in the setting of CIPN, in a multiarm comparative human trial. A random effects DerSimonian-Laird model was used to calculate summary risk ratios (RR) and corresponding 95% CIs, comparing duloxetine to placebo.
Results: Seven randomised controlled trials that included 645 patients were identified. Five reported on duloxetine for treatment of CIPN, and two for prevention of CIPN. Two studies had some concern for bias. Duloxetine was statistically similar to placebo in its efficacy, both in the treatment (RR 0.92, 95% CI 0.84 to 1.01) and prevention (RR 1.02, 95% CI 0.87 to 1.19) of CIPN. Safety profile was similar, in the treatment (RR 1.31, 95% CI 0.90 to 1.89) and prevention (RR 1.52, 95% CI 0.98 to 2.38) setting.
Conclusion: There is currently limited evidence supporting duloxetine’s use for CIPN. There is a need for more comprehensive and higher-quality trials assessing duloxetine in the setting of CIPN, before further clinical practice recommendations.
Dr. Alfonso‘s Neuropathy Treatment Protocol…..
Dr. Alfonso‘s Neuropathy Treatment Protocol utilizes 8 specialized treatments designed to improve the supply of oxygen, eliminate waste, and improve nutrition to damaged nerves.
Increased circulation to the damaged peripheral nerves combined with treatments to stimulate peripheral nerve cell regeneration, and repair.
Dr. Alfonso Neuropathy Treatment Protocol
● Improves and increases oxygen and nutrition through the increase of circulation to the damaged nerves.
● Repairs peripheral fibers by stimulating regeneration of new nerve cells.
● Removes and eliminates mechanical peripheral nerve entrapments and compressions in the spine and extremities.
The first step to recovering your health is to determine the cause of your symptoms, identify your current nerve damage severity, and design an individualized peripheral neuropathy
treatment plan of action to help you beat peripheral neuropathy.
Dr. Alfonso will select the best treatment therapy combination, frequency, nutritional plan, and home support determined from your consultation, examination and diagnostics.
For more info on the Dr. Alfonso Neuropathy Treatment Protocol please visit our treatment page of our website.
Please contact our Miami office (305) 275-7475 and schedule an appointment so you can learn about a new innovative peripheral neuropathy treatment that has improved the lives of patients not only in Miami, Florida but from across the world.
We look forward to helping you recover your health!
Dr. Rodolfo Alfonso, D.C.
Neuropathy Relief Center Of Miami
8585 Sunset Dr. STE 104
Miami, Florida 33143